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Creators/Authors contains: "Tokarz, Danielle"

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  1. ; ; ; ; ; ; ; ; ; ; et al (, SPIE)
    Evans, Conor L; Chan, Kin Foong (Ed.)
    Pancreatic ductal adenocarcinoma continues to be one of the most lethal cancers today with an abysmal ~8% 5- year survival rate that has remained relatively constant over time. This is thought to be largely due the desmoplastic stroma in the extracellular matrix of these tumor types, inhibiting both the penetration as well as target engagement of treatments. Here we present a methodology for evaluating a monoclonal antibody’s drug target engagement in the presence of an extracellular matrix remodeling drug using paired-agent imaging principles and a subcutaneous tumor mouse model. 
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